The implications are that resveratrol supplementation exerts anti-obesity effects and improves metabolic syndrome –a cluster of conditions such as high blood pressure, high blood sugar, undesirable cholesterol and triglyceride levels, and excess body fat around the waist.
How exactly it does all that is up for scientific conjecture. True, resveratrol is a natural antioxidant, but frankly, so is just about anything that comes from a plant and is digestible by animals. A more plausible (but much harder to explain or understand) explanation, first suggested by Zhang (2019), is that the beneficial effects of resveratrol are related to changes “in the expression of several lipid metabolism-related MiRNAs (microRNAs) and genes.”
Another researcher, Zhuang (2019), tossed out another equally plausible but much easier-to-understand mechanism for resveratrol’s effects on metabolism. He and his colleagues thought that the polyphenol improved gut immune response and microbiota function.
People carrying the right amounts and right kinds of gut microbes tend to lose body fat for a couple of reasons. Firstly, certain beneficial gut microbes produce enzymes that help break down complex carbohydrates into simple sugars, making them easier to digest and less likely to take up residence on your waistline.
Further, certain bacteria produce higher levels of short-chain fatty acids that reduce inflammation and seem to facilitate fat loss.
We don’t know if that’s the case with Zhou’s meta-study, but the effects certainly jibe with his findings.